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Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal

Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang

《医学前沿（英文）》 2020年 第14卷 第1期   页码 91-100 doi: 10.1007/s11684-019-0696-6

摘要： Pancreatic ductal adenocarcinoma (PDAC) is the ninth most common human malignancy and the sixth leading cause of cancer-related death in China. AcK27-HOXB9 is a newly identified HOXB9 post-transcriptional modification that can predict the outcome in lung adenocarcinoma and colon cancer well. However, the role of AcK27-HOXB9 in PDAC is unclear. The present study aims to investigate the differential diagnostic role of patients with AcK27-HOXB9 PDAC. Tissue microarrays consisting of 162 pancreatic tumor tissue samples from patients with PDAC and paired normal subjects were used to examine HOXB9 and AcK27-HOXB9 levels and localizations by immunohistochemical analysis and Western blot assay, respectively. HOXB9 was upregulated ( <0.0001), and AcK27-HOXB9 ( =0.0023) was downregulated in patients with PDAC. HOXB9 promoted ( =0.0115), while AcK27-HOXB9 ( =0.0279) inhibited PDAC progression. AcK27-HOXB9 predicted favorable outcome in patients with PDAC ( =0.0412). AcK27-HOXB9 also suppressed PDAC cell migration in a cell migration assay. The results of this study showed that HOXB9 promoted and AcK27-HOXB9 suppressed PDAC progression. The determination of ratio between HOXB9 and AcK27-HOXB9 exhibited potential diagnostic value in patients with PDAC.

关键词： HOXB9     AcK27-HOXB9     PDAC    

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Development of an artificial intelligence diagnostic model based on dynamic uncertain causality graphfor the differential diagnosis of dyspnea

Yang Jiao, Zhan Zhang, Ting Zhang, Wen Shi, Yan Zhu, Jie Hu, Qin Zhang

《医学前沿（英文）》 2020年 第14卷 第4期   页码 488-497 doi: 10.1007/s11684-020-0762-0

摘要： Dyspnea is one of the most common manifestations of patients with pulmonary disease, myocardial dysfunction, and neuromuscular disorder, among other conditions. Identifying the causes of dyspnea in clinical practice, especially for the general practitioner, remains a challenge. This pilot study aimed to develop a computer-aided tool for improving the efficiency of differential diagnosis. The disease set with dyspnea as the chief complaint was established on the basis of clinical experience and epidemiological data. Differential diagnosis approaches were established and optimized by clinical experts. The artificial intelligence (AI) diagnosis model was constructed according to the dynamic uncertain causality graph knowledge-based editor. Twenty-eight diseases and syndromes were included in the disease set. The model contained 132 variables of symptoms, signs, and serological and imaging parameters. Medical records from the electronic hospital records of Suining Central Hospital were randomly selected. A total of 202 discharged patients with dyspnea as the chief complaint were included for verification, in which the diagnoses of 195 cases were coincident with the record certified as correct. The overall diagnostic accuracy rate of the model was 96.5%. In conclusion, the diagnostic accuracy of the AI model is promising and may compensate for the limitation of medical experience.

关键词： knowledge representation     uncertain     causality     graphical model     artificial intelligence     diagnosis     dyspnea    

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A case of big substernal goiter resection

SONG Jiangping, LIAO Hongying, YU Chao, ZHANG Jian, Li Yun, GU Lijia

《医学前沿（英文）》 2008年 第2卷 第4期   页码 410-413 doi: 10.1007/s11684-008-0079-x

摘要： Substernal goiter is considered to be a diagnostic differential for all anterosuperior mediastinal masses. For a substernal goiter, surgical removal is suggested when it is large in size, with a possibility for malignancy or has local compression of adjacent structures. This can be performed through the neck or by the addition of a partial or complete sternotomy if necessary. A 58-year-old Chinese man from Guangdong Province had had dry cough for a year. A subsequent CT scan in our hospital suggested “ectopic intrathoracic thyroid”. Fine needle percutaneous mass biopsy also suggested “ectopic intrathoracic thyroid”. We performed a standard median sternotomy to remove the mass. It measured 13 cm × 8 cm × 6 cm in size, and weighed 2.8 kg. The pathological diagnosis confirmed a benign thyroid adenoma. The patient had no hoarseness, dyspnea or hypocalcemia and was quickly extubated in the operating room. Recently, we encountered a big substernal goiter and had performed successful resection, which is reported here for reference.

关键词： percutaneous     diagnostic differential     necessary     compression     intrathoracic    

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

《医学前沿（英文）》 2022年 第16卷 第5期   页码 723-735 doi: 10.1007/s11684-021-0905-y

摘要： Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. At present, no definite ALS biomarkers are available. In this study, exosomes from the plasma of patients with ALS and healthy controls were extracted, and differentially expressed exosomal proteins were compared. Among them, the expression of exosomal coronin-1a (CORO1A) was 5.3-fold higher than that in the controls. CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice. CORO1A was also overexpressed in NSC-34 motor neuron-like cells, and apoptosis, oxidative stress, and autophagic protein expression were evaluated. CORO1A overexpression resulted in increased apoptosis and oxidative stress, overactivated autophagy, and hindered the formation of autolysosomes. Moreover, CORO1A activated Ca2+-dependent phosphatase calcineurin, thereby blocking the fusion of autophagosomes and lysosomes. The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes. In conclusion, the role of CORO1A in ALS pathogenesis was discovered, potentially affecting the disease onset and progression by blocking autophagic flux. Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

关键词： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

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Obesity in China: its characteristics, diagnostic criteria, and implications

null

《医学前沿（英文）》 2015年 第9卷 第2期   页码 129-133 doi: 10.1007/s11684-015-0387-x

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Tuned reactive power dispatch through modified differential evolution technique

S. BISWAS (RAHA), N. CHAKRABORTY

《能源前沿（英文）》 2012年 第6卷 第2期   页码 138-147 doi: 10.1007/s11708-012-0188-8

摘要： This paper explores the capability of modified differential evolution (MDE) technique for solving the reactive power dispatch (RPD) problem. The proposed method is based on the basic differential evolution (DE) technique with a few modifications made into it. DE is one of the strongest optimization techniques though it suffers from the problem of slow convergence while global minima appear. The proposed modifications are tried to resolve the problem. The RPD problem mainly defines loss minimization with stable voltage profile. To solve the RPD problem, the generator bus voltage, transformer tap setting and shunt capacitor placements are controlled by the MDE approach. In this paper, IEEE 14-bus and IEEE 30-bus systems are chosen for MDE implementation. The applied modification show much improved result in comparison to normal DE technique. Comparative study with other soft-computing technique including DE validates the effectiveness of the proposed method.

关键词： reactive power dispatch (RPD)     modified differential evolution (MDE)     differential evolution algorithm with localizations around the best vector (DELB)    

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Review of MEMS differential scanning calorimetry for biomolecular study

Shifeng YU, Shuyu WANG, Ming LU, Lei ZUO

《机械工程前沿（英文）》 2017年 第12卷 第4期   页码 526-538 doi: 10.1007/s11465-017-0451-0

摘要：

Differential scanning calorimetry (DSC) is one of the few techniques that allow direct determination of enthalpy values for binding reactions and conformational transitions in biomolecules. It provides the thermodynamics information of the biomolecules which consists of Gibbs free energy, enthalpy and entropy in a straightforward manner that enables deep understanding of the structure function relationship in biomolecules such as the folding/unfolding of protein and DNA, and ligand bindings. This review provides an up to date overview of the applications of DSC in biomolecular study such as the bovine serum albumin denaturation study, the relationship between the melting point of lysozyme and the scanning rate. We also introduce the recent advances of the development of micro-electro-mechanic-system (MEMS) based DSCs.

关键词： differential scanning calorimetry     biomolecule     MEMS     thermodynamic    

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Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

《医学前沿（英文）》 2007年 第1卷 第1期   页码 109-114 doi: 10.1007/s11684-007-0021-7

摘要： The overall diagnostic capabilities and utility of frequency-doubling technology (FDT) in patients with primary glaucoma, which was diagnosed by standard automated perimetry (SAP) and/or optic disc appearance as the gold standard, were assessed. A comprehensive electric retrieval in MEDLINE, EMBASE, Cochrane Library, BIOSIS, Previews, HMIC, IPA, OVID, CNKI, CBMdisc, VIP information, CMCC, CCPD, SSreader, 21dmedia and manual retrieval in related textbooks, journals, congress articles and their references at home and abroad were performed to identify relevant articles in English or Chinese. The corresponding references were retrieved by means of electric retrieval and manual retrieval from different databases or materials. Criteria for inclusion or exclusion were established according to validity criteria for diagnostic studies published by the Cochrane Methods Group on Screening and Diagnostic Tests. The quality of the included articles was then assessed and characteristics were extracted. Statistical analysis was performed with Meta Test version 0.6 software to test the heterogeneity of the included articles. The appropriate effects model was selected to calculate pooled weighted sensitivity and specificity. Summary receiver operating characteristic (SROC) curve was drawn and the area under the curve (AUC) was calculated. Finally, sensitivity analysis was performed. Twenty-one studies out of 206 retrieved articles were included, with a total of 3172 patients. The reported sensitivity of FDT ranged from 0.51 to 1.00, and specificity from 0.58 to 1.00. The pooled weighted sensitivity and specificity of FDT with 95% confidence intervals (95% CI) after correction for standard error were 0.86 (0.80 0.90) and 0.87 (0.81 0.91), respectively. The AUC of SROC was 93.01%. Sensitivity analysis demonstrated no disproportionate influences of individual studies. The included articles are of good quality and FDT can be a highly efficient diagnostic test for primary glaucoma based on Meta-analysis.

关键词： inclusion     sensitivity analysis     correction     specificity     appropriate    

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面向机床的可重构监测诊断系统开发与应用

景敏卿,李猛,刘恒

《中国工程科学》 2013年 第15卷 第1期   页码 34-38

摘要：

提出了一种基于“系统引擎+功能组件”的监测诊断系统平台架构，并针对机床4大功能部件模块，设计了3类（振动、功率和声发射）嵌入式监测单元，以强化底层监测信息获取的实时性和灵活性。笔者还开发了一系列机床常规监测诊断组件，并针对具有特殊监测诊断需求的数控机床功能部件，开发了相应的特殊功能组件，通过对功能组件的封装和加载实现具有特定需求的机床监测诊断系统，并在秦川磨床厂和大连机床厂进行实际应用。

关键词： 机床监测诊断系统     可重构     系统引擎     功能组件    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

null

《医学前沿（英文）》 2013年 第7卷 第4期   页码 506-509 doi: 10.1007/s11684-013-0294-y

摘要：

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in the city of Lhasa, China. Seven out of the twenty-six hospitals registered with the Lhasa Health Bureau were included in the investigation. The entrance surface air Kerma (ESAK) of seven conventional screen-film radiology X-ray equipment in these hospitals was measured with a QA dosimeter in September 2012. The X-ray examinations were divided into three categories: PA (posterior-anterior) chest, upper/lower limb, and AP (anterior-posterior) lumbar spine. For each category, ESAKs were calculated and analyzed. The mean ESAK was 0.6 mGy for PA chest, 0.3 mGy for upper/lower limb, and 1.8 mGy for AP lumbar spine. In addition, the mean ESAK value recorded for PA chest X-ray examinations exceeded the corresponding value recommended by the International Atomic Energy Agency (0.4 mGy).

关键词： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

《医学前沿（英文）》 2012年 第6卷 第3期   页码 243-247 doi: 10.1007/s11684-012-0201-y

摘要： Diabetes has become a major public health problem in China nowadays. There are almost 97 million diabetic patients nationwide. Latent autoimmune diabetes in adults (LADA) is a subtype of autoimmune diabetes. Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversial. The discussion mainly focused on serum autoantibodies, period of insulin need and age of diagnosis. Besides, β cell function, metabolic parameters, genetic factors and cell immunity may also contribute to the formulation of the criteria. Here, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.

关键词： LADA     diagnostic criteria     autoantibodies     insulin independence     age of diagnosis    

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treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic

《医学前沿（英文）》 2022年 第16卷 第6期   页码 827-858 doi: 10.1007/s11684-022-0948-8

摘要： Infertility is experienced by 8%–12% of adults in their reproductive period globally and has become a prevalent concern. Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapies in regenerative medicine and translational investigation. Remarkable progress has been made in understanding the biology and purpose of stem cells. The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied for their possible use in reproductive medicine, particularly for infertility induced by premature ovarian insufficiency and azoospermia. Accordingly, this study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem cells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs. These methods have been used to manage ovarian and uterine disorders, and each technique presents a novel method for the therapy of infertility.

关键词： infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

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Real-world fuel consumption of light-duty passenger vehicles using on-board diagnostic (OBD) systems

Xuan Zheng, Sheng Lu, Liuhanzi Yang, Min Yan, Guangyi Xu, Xiaomeng Wu, Lixin Fu, Ye Wu

《环境科学与工程前沿（英文）》 2020年 第14卷 第2期 doi: 10.1007/s11783-019-1212-6

摘要： • Fuel consumption (FC) from LDPVs is measured using on-board diagnostic method (OBD). • The FC of the OBD is 7.1% lower than that of the carbon balance results. • The discrepancy between the approved FC and real-world FC is 13%±18%. • There is a strong relationship (R2=0.984) between the average speed and relative FC. An increasing discrepancy between real-world and type-approval fuel consumption for light-duty passenger vehicles (LDPVs) has been reported by several studies. Normally, real-world fuel consumption is measured primarily by a portable emission measurement system. The on-board diagnostic (OBD) approach, which is flexible and offers high-resolution data collection, is a promising fuel consumption monitoring method. Three LDPVs were tested with a laboratory dynamometer based on a type-approval cycle, the New European Driving Cycle (NEDC). Fuel consumption was measured by the OBD and constant-volume sampling system (CVS, a regulatory method) to verify the accuracy of the OBD values. The results of the OBD method and the regulatory carbon balance method exhibited a strong linear correlation (e.g., R2 = 0.906-0.977). Compared with the carbon balance results, the fuel consumption results using the OBD were 7.1%±4.3% lower on average. Furthermore, the real-world fuel consumption of six LDPVs was tested in Beijing using the OBD. The results showed that the normalized NEDC real-world fuel consumption of the tested vehicles was 13%±17% higher than the type-approval-based fuel consumption. Because the OBD values are lower than the actual fuel consumption, using a carbon balance method may result in a larger discrepancy between real-word and type-approval fuel consumption. By means of the operating mode binning and micro trip methods, a strong relationship (R2 = 0.984) was established between the average speed and relative fuel consumption. For congested roads (average vehicle speed less than 25 km/h), the fuel consumption of LDPVs is highly sensitive to changes in average speed.

关键词： Fuel consumption     Light-duty passenger vehicles     On-board diagnostic systems    

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Intelligent fault diagnostic system based on RBR for the gearbox of rolling mills

Lixin GAO, Lijuan WU, Yan WANG, Houpei WEI, Hui YE

《机械工程前沿（英文）》 2010年 第5卷 第4期   页码 483-490 doi: 10.1007/s11465-010-0118-6

摘要： This paper presents an intelligent system that is necessary for diagnostic accuracy and efficiency in the iron and steel industry. A rule-based reseaning (RBR) intelligent diagnostic system has been developed based on many successful diagnostic applications. It can solve the difficulty in knowledge acquisition and has more precision. Its application results prove that the usability of the system is good and it will increasingly attain perfection.

关键词： rule-based reasoning     fault diagnosis     intelligent system     gear box    

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Solving multi-objective optimal power flow problem considering wind-STATCOM using differential evolution

Belkacem MAHDAD, K. SRAIRI

《能源前沿（英文）》 2013年 第7卷 第1期   页码 75-89 doi: 10.1007/s11708-012-0222-x

摘要： In this paper, a simple strategy based differential evolution was proposed for solving the problem of multi-objective environmental optimal power flow considering a hybrid model (Wind-Shunt-FACTS). The DE algorithm optimized simultaneously a combined vector control based active power of wind sources and reactive power of multi STATCOM exchanged with the electrical power system to minimize fuel cost and emissions. The proposed strategy was examined and applied to the standard IEEE 30-bus with smooth cost function to solve the problem of security environmental economic dispatch considering multi distributed hybrid model based wind and STATCOM controllers. In addition, the proposed approach was validated on a large practical electrical power system 40 generating units considering valve point effect. Simulation results demonstrate that choosing the installation of multi type of FACTS devices in coordination with many distributed wind sources is a vital research area.

关键词： differential evolution     multi-objective function     optimal power flow     economic dispatch     valve point effect     environment     wind source     STATCOM    

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标题 作者 时间 类型 操作

Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal

Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang

期刊论文

Development of an artificial intelligence diagnostic model based on dynamic uncertain causality graphfor the differential diagnosis of dyspnea

Yang Jiao, Zhan Zhang, Ting Zhang, Wen Shi, Yan Zhu, Jie Hu, Qin Zhang

期刊论文

A case of big substernal goiter resection

SONG Jiangping, LIAO Hongying, YU Chao, ZHANG Jian, Li Yun, GU Lijia

期刊论文

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

期刊论文

Obesity in China: its characteristics, diagnostic criteria, and implications

null

期刊论文

Tuned reactive power dispatch through modified differential evolution technique

S. BISWAS (RAHA), N. CHAKRABORTY

期刊论文

Review of MEMS differential scanning calorimetry for biomolecular study

Shifeng YU, Shuyu WANG, Ming LU, Lei ZUO

期刊论文

Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

期刊论文

面向机床的可重构监测诊断系统开发与应用

景敏卿,李猛,刘恒

期刊论文

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

null

期刊论文

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

期刊论文

treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic

期刊论文

Real-world fuel consumption of light-duty passenger vehicles using on-board diagnostic (OBD) systems

Xuan Zheng, Sheng Lu, Liuhanzi Yang, Min Yan, Guangyi Xu, Xiaomeng Wu, Lixin Fu, Ye Wu

期刊论文

Intelligent fault diagnostic system based on RBR for the gearbox of rolling mills

Lixin GAO, Lijuan WU, Yan WANG, Houpei WEI, Hui YE

期刊论文

Solving multi-objective optimal power flow problem considering wind-STATCOM using differential evolution

Belkacem MAHDAD, K. SRAIRI

期刊论文